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New approaches of the hypertension treatment: from choosing the best drug to choose the optimum drugs combination

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Author(s): O.D. Ostroumova | E.A. Smolyarchuk | I.V. Khvorostyanaya

Journal: Racionalʹnaâ Farmakoterapiâ v Kardiologii
ISSN 1819-6446

Volume: 6;
Issue: 5;
Start page: 709;
Date: 2010;
Original page

Keywords: hypertension | combined antihypertensive therapy | ACE inhibitors | calcium antagonists | thiazide diuretics.

ABSTRACT
The possible indications for the choice of two component antihypertensives combinations are presented. The advantages of ACE inhibitor+calcium channel blocker combination are shown in terms of antihypertensive efficacy, organoprotective properties, and positive metabolic effects. Clinical aspects of ACE inhibitor+thiazide diuretic combination usage, its possible side effects and ways to minimize them are considered.
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