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A New Atisane-Type Diterpene from the Bark of the Mangrove Plant Excoecaria Agallocha

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Author(s): Zhan Chang Wang | Yi Ming Lin | Dan Qin Feng | Cai Huan Ke | Peng Lin | Chong Ling Yan | Jun De Chen

Journal: Molecules
ISSN 1420-3049

Volume: 14;
Issue: 1;
Start page: 414;
Date: 2009;
Original page

Keywords: Diterpenes | Biofilm | Excoecaria agallocha | Anti-microfouling

ABSTRACT
A new atisane-type diterpene, ent-16α-hydroxy-atisane-3,4-lactone (4) and three known diterpenes, ent-16α-hydroxy-atisane-3-one (1), ent-atisane-3β,16α-diol (2), ent-3,4-seco-16α-hydroxyatis- 4(19)-en -3-oic acid (3) were isolated from the bark of the mangrove plant Excoecaria agallocha. Their structures and relative stereochemistry were elucidated by means of extensive NMR and MS analysis. Compound 3 exhibited significant anti-microfouling activity against the adherence of Pseudomonas pseudoalcaligenes, with an EC50 value of 0.54 ± 0.01 ppm.

Tango Jona
Tangokurs Rapperswil-Jona

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