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New Cembrane Diterpenoids from a Hainan Soft Coral Sinularia sp.

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Author(s): Bin Yang | Xuefeng Zhou | Hui Huang | Xian-Wen Yang | Juan Liu | Xiuping Lin | Xiubao Li | Yan Peng | Yonghong Liu

Journal: Marine Drugs
ISSN 1660-3397

Volume: 10;
Issue: 9;
Start page: 2023;
Date: 2012;
Original page

Keywords: Sinularia sp. | cembrane diterpenoids | NF-κB inhibitor

ABSTRACT
Five new cembrane diterpenoids, named sinuflexibilins A–E (1–5), along with nine other known diterpenoids (6–14), have been isolated from the organic extract of a Hainan soft coral Sinularia sp. Their structures were determined on the basis of extensive spectroscopic analyses and by comparison of their spectral data with those of related metabolites. Compound 13, flexibilide, exhibited significant inhibitory activity of NF-κB activation using the cell-based HEK293 NF-κB luciferase reporter gene assay.
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