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New Cembranolides from the Dongsha Atoll Soft Coral Lobophytum durum

Author(s): Shi-Yie Cheng | Pei-Wen Chen | Hwa-Pyng Chen | Shang-Kwei Wang | Chang-Yih Duh

Journal: Marine Drugs
ISSN 1660-3397

Volume: 9;
Issue: 8;
Start page: 1307;
Date: 2011;
Original page

Keywords: soft coral | Lobophytum durum | cytotoxicity | antiviral activity

Chemical investigations of the Dongsha Atoll soft coral Lobophytum durum resulted in the isolation of five new cembranolides, durumolides M–Q (1–5). The structures of compounds 1–5 were characterized by the interpretation of extensive spectroscopic analysis. Compound 4 exhibited cytotoxicity against P-388 (mouse lymphocytic leukemia) cell line with an ED50 of 3.8 μg/mL. Moreover, compound 5 showed significant antiviral activity against human cytomegalovirus with an IC50 of 5.2 μg/mL.
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