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A New Cytotoxic Sesquiterpene Quinone Produced by Penicillium sp. F00120 Isolated from a Deep Sea Sediment Sample

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Author(s): Xiuping Lin | Xuefeng Zhou | Fazuo Wang | Kaisheng Liu | Bin Yang | Xianwen Yang | Yan Peng | Juan Liu | Zhe Ren | Yonghong Liu

Journal: Marine Drugs
ISSN 1660-3397

Volume: 10;
Issue: 1;
Start page: 106;
Date: 2012;
Original page

Keywords: Penicillium sp. F00120 | sesquiterpene quinone | cytotoxic | deep sea sediment | penicilliumin A

ABSTRACT
A new fungal strain, displaying strong toxic activity against brine shrimp larvae, was isolated from a deep sea sediment sample collected at a depth of 1300 m. The strain, designated as F00120, was identified as a member of the genus Penicillium on the basis of morphology and ITS sequence analysis. One new sesquiterpene quinone, named penicilliumin A (1), along with two known compounds ergosterol (2) and ergosterol peroxide (3), were isolated and purified from the cultures of F00120 by silica gel column, Sephadex LH-20 column, and preparative thin layer chromatography. Their structures were elucidated by detailed nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analysis as well as comparison with literature data. The new compound penicilliumin A inhibited in vitro proliferation of mouse melanoma (B16), human melanoma (A375), and human cervical carcinoma (Hela) cell lines moderately.

Tango Jona
Tangokurs Rapperswil-Jona

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