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New Derivatives from Phencyclidine Increase Food and Water Intake in Wistar Rats

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Author(s): A. Ahmadi | J. Solati | M. khalili

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 9;
Issue: 2;
Start page: 77;
Date: 2010;
Original page

Keywords: Phencyclidine Derivatives | Pharmacological Effects | Food and Water Intake

ABSTRACT
Phencyclidine (1-(1-phenylcyclohexyl) piperidine, CAS 956-90-1, PCP, I) and its derivatives have shown many pharmacological and behavioral effects. Also, food and water intake of many drugs such as PCP and its analogues have been studied in laboratory animals. In this work, two derivatives (II, III) of phencyclidine were tested for feeding behaviors effects on rats and compared to PCP and vehicle (saline). The results showed that, both derivatives can increase food and water intake in comparison to the PCP and vehicle (control) groups that have measured 1-12 h for food and 30–180 min for water intake after injection.

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