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New form of administering chlorhexidine for treatment of denture-induced stomatitis

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Author(s): Ryalat S | Darwish R | Amin W

Journal: Therapeutics and Clinical Risk Management
ISSN 1176-6336

Volume: 2011;
Issue: default;
Start page: 219;
Date: 2011;
Original page

ABSTRACT
Soukaina Ryalat, Rula Darwish, Wala AminDepartment of Oral Surgery, Jordan University, Amman, JordanBackground: The purpose of this study was to evaluate the release of chlorhexidine as an antifungal drug from doped self-cured poly (methyl methacrylate) (PMMA) acrylic resin and the effect of the drug released on the growth of Candida albicans.Methods: Release of chlorhexidine was evaluated using liquid chromatography, and the effect of the drug on the growth of C. albicans was investigated microbiologically using a “well” technique on Saboraud culture medium inoculated with a resistant strain of C. albicans.Results: Chlorhexidine leached steadily out of the acrylic resin into distilled water at mouth temperature, and the sustained drug release continued throughout the 28-day test period. The drug released also demonstrated antifungal activity against the resistant strain of C. albicans.Conclusion: The findings of this study support the use of chlorhexidine-impregnated self-cured PMMA chair-side resin as a new dosage form for the treatment of denture-induced stomatitis.Keywords: chlorhexidine, poly (methyl methacrylate), eluates, antifungal drug, denture stomatitis, Candida albicans

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