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A NEW ROUTE FOR THE SYNTHESIS OF 2 AMINOPYRIDINES

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Author(s): Zahira Kibou | Nawel Cheikh | Noureddine Choukchou-Braham | Bachir Mostefa-Kara | Mohammed Benabdellah | Didier Villemin

Journal: Scientific Study & Research. Chemistry & Chemical Engineering, Biotechnology, Food Industry
ISSN 1582-540X

Volume: 12;
Issue: 2;
Start page: 121;
Date: 2011;
Original page

Keywords: 2-amino-3-cyanopyridines | enaminonitriles | green chemistry | microwave | solvent-free

ABSTRACT
The 2-aminopyridines constitute a very large class of nitrogen heterocycles, which have a great biological activity, such as the antibacterial, anti-inflammatory and analgesics activity, as well as the 2-amino-4-(4-chlorophenyl)-5-oxo-5,6,7,8-tetrahydroquinoline-3-carbonitrile has a antifungal activity. A new approach of synthesis of 2 amino-3-cyanopyridines was developed in our laboratory, based on the condensation of the intermediary of enaminonitrile with different primary amines in solvent-free environments.
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