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New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp.

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Author(s): Bin Yang | Shengrong Liao | Xiuping Lin | Junfeng Wang | Juan Liu | Xuefeng Zhou | Xianwen Yang | Yonghong Liu

Journal: Marine Drugs
ISSN 1660-3397

Volume: 11;
Issue: 12;
Start page: 4741;
Date: 2013;
Original page

Keywords: soft coral | Sinularia sp. | sesquiterpenes | sinularianins | NF-κB

ABSTRACT
Four new sesquiterpenes, sinularianins C–F (3–6), together with known sinularianins A (1) and B (2) were identified from a South China Sea soft coral Sinularia sp. Compounds 1–6 were evaluated for inhibition of NF-κB activation using the cell-based HEK293 NF-κB luciferase reporter gene assay. Compounds 1 and 4 were exhibited a potent effect with inhibitory rates of 41.3% and 43.0% at the concentration of 10 µg/mL, respectively.
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