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A New Target in Non-small Cell Lung Cancer: EML4-ALK Fusion Gene

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Author(s): Huijuan WANG | Jing YUAN | Zhiyong MA

Journal: Chinese Journal of Lung Cancer
ISSN 1009-3419

Volume: 14;
Issue: 6;
Start page: 538;
Date: 2011;
Original page

Keywords: EML4-ALK | Anaplastic lymphoma kinase | Lung neoplasms

ABSTRACT
It was only 3 years ago that the fusion gene between echinoderm microtubule-associated protein-like4 (EML4) and anaplastic lymphoma kinase (ALK) has been identified in a subset of non-small cell lung cancer (NSCLC). EML4-ALK is most often detected in never smokers with lung adenocarcinoma and has unique pathologic features. EML4-ALK fusion gene is oncogenic, which could be suppressed by ALK-inhibitor through blocking the downstream signaling passway of EML4-ALK. This review will focus on the molecular structure, function, biology, detection method and the diagnostic and therapeutic meaning of EML4-ALK of lung cancer.
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