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A New Vanadium Complex Improves the Spatial Learning and Memory by Activation of Caveolin–MAPK–CREB Pathway in Diabetic Mice

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Author(s): Dr. Wei Zou

Journal: Journal of Diabetes & Metabolism
ISSN 2155-6156

Volume: 2;
Issue: 1;
Date: 2011;
Original page

Keywords: Diabetes | Vanadium | Caveolin-1 | Learning and memory

ABSTRACT
Diabetic encephalopathy, characterized by impaired spatial cognitive functions and the decline of learning and memory ability, involves direct neuronal damage caused by intracellular glucose. Vanadium, a required trace element of human body, is reported that it can reduce the blood glucose values of glycemia animals and has an effect on the treatment of diabetes complications. To investigate the role of vanadium in the pathogenesis of diabetic cognitive function impediment, Kunming mice were divided into control group, diabetes group and vanadium-treatment group. Diabetic mice were induced by intraperitoneal injection of 200 mg/kg of alloxan and in vanadium-treatment group diabetic mice were treated by intragastric infusion for three weeks with 5 mg/kg of VO(HB(3,5-Me2pz)3)(3,5-Me2pzH)(SCN)(SCNH)2, a new vanadium complex with 3,5-dimethyl-pyrazolyl ligand and relative lower toxicity. The three groups were trained by Morris water maze and then the expression of proteins related to learning and memory in the hippocampus of mice were examined by Western blot. The results showed that (1) the latency to find platform was longer (p>0.05) and the percent time in target quadrant was lower (p
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