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Next Generation Sequencing of Ancient DNA: Requirements, Strategies and Perspectives

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Author(s): Michael Knapp | Michael Hofreiter

Journal: Genes
ISSN 2073-4425

Volume: 1;
Issue: 2;
Start page: 227;
Date: 2010;
Original page

Keywords: ancient DNA | barcoding | genome sequencing | hybridization capture | targeted sequencing

ABSTRACT
The invention of next-generation-sequencing has revolutionized almost all fields of genetics, but few have profited from it as much as the field of ancient DNA research. From its beginnings as an interesting but rather marginal discipline, ancient DNA research is now on its way into the centre of evolutionary biology. In less than a year from its invention next-generation-sequencing had increased the amount of DNA sequence data available from extinct organisms by several orders of magnitude. Ancient DNA  research is now not only adding a temporal aspect to evolutionary studies and allowing for the observation of evolution in real time, it also provides important data to help understand the origins of our own species. Here we review progress that has been made in next-generation-sequencing of ancient DNA over the past five years and evaluate sequencing strategies and future directions.

Tango Jona
Tangokurs Rapperswil-Jona

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