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nfluence of metoprolol succinate on regulatory and adaptive status of patients with chronic heart failure functional class I. Results of not comparative study

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Author(s): V.G. Tregubov | S.G. Kanorskiy | V.M. Pokrovskiy

Journal: Racionalʹnaâ Farmakoterapiâ v Kardiologii
ISSN 1819-6446

Volume: 7;
Issue: 6;
Start page: 752;
Date: 2011;
Original page

Keywords: сhronic heart failure | metoprolol succinate | сardio-respiratory synchronism | regulatory and adaptive status.

ABSTRACT
Aim. To estimate metoprolol succinate effect on regulatory and adaptive status (RAS) of patients with сhronic heart failure (CHF) functional class (FC) I and arterial hypertension (HT) I-II stages.Material and methods. 51 patients with CHF FC I and HT I-II stage, (30 men and 21 women aged 52.6±1.4 yeas). Cardio-respiratory synchronism (CRS) test, 6-minute walking test, treadmill burden test with registration of maximal oxygen consumption, 24-hour blood pressure monitoring, echocardiography and determination of N-terminal pro-brain natriuretic peptide (NT-proBNP) blood level were performed initially and after 6 months of therapy with metoprolol succinate (dose 78.1±5.7 mg/day) in sustained-release presentation.Results. Metoprolol succinate therapy had no significant effect on RAS (there was no unidirectional dynamics of the basic CRS test parameters: a range of synchronization decreased significantly from 8.8±0.4 to 7.2±0.6 сardio-respiratory cycles per minute (in 18%; р
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