Academic Journals Database
Disseminating quality controlled scientific knowledge

Nitrated and Brominated Narcotine and its Cleaved Adduct as Butyrylcholinesterase Inhibitors

ADD TO MY LIST
 
Author(s): M. A. Abbasi | Aziz-ur-Rehman | M. Z. Qureshi | M. S. Shahid | S. Rasool | M. Ashraf

Journal: Pakistan Journal of Chemistry
ISSN 2220-2625

Volume: 3;
Issue: 3;
Start page: 129;
Date: 2013;
VIEW PDF   PDF DOWNLOAD PDF   Download PDF Original page

Keywords: Bromination | Butyrylcholinesterase | Narcotine | Nitration | Cleaved adducts.

ABSTRACT
Narcotine is a very antitussive agent and its modification may lead to some more biological activities. In this presented paper, narcotine (1) was first subjected to nitration and bromination to yield nitrated narcotine (2) and brominated narcotine (3). It wasfurther made to react with phenylchloroformate (6) to give a cleaved addition product 4. This adduct 4 was further nitrated and brominated to yield substituted derivatives 5 and 6, respectively. The structure elucidation of the synthesized compounds was processed via IR, EI-MS and 1H-NMR spectra. These were also screened against butyrylcholinesterase enzyme and were found to the moderate inhibitors of butyrylcholinesterase except nitrated product, 2, of narcotine (1).
Why do you need a reservation system?      Save time & money - Smart Internet Solutions