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NMRI mice as biomodel in the micronuclei assay

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Author(s): Daniel Francisco Arencibia Arrebola | Luis Alfredo Rosario Fernández | Yolanda Emilia Suárez Fernández | Livan Delgado Roche

Journal: RETEL : Revista de Toxicología en Línea
ISSN 1668-091X

Volume: 31;
Start page: 21;
Date: 2010;
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Keywords: Spontaneous | induced | micronuclei assay | NMRI mice | cyclophosphamide

ABSTRACT
The micronuclei assay in bone marrow, is one of those included at the moment inside the toxicologics battery of obligatory studies demanded by numerous regulatory agencies, it is easily to reproduce and it offers clear information on the cellular proliferation in bone marrow. This system allows registering in vivo the capacity of the chemical substances to induce chromosomics ruptures to interfere or the chromosomes metaphases migration during the mitosis of the somatic cells. In this article we reported the basal frequency of micronuclei in bone marrow of NMRI mice of both sexes; as well as the events induced frequency after the cyclophosphamide administration by intraperitoneal route (50 mg/kg), mutagen reference used as positive control.
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