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No association between polymorphisms/haplotypes of the vascular endothelial growth factor gene and preeclampsia

Author(s): Garza-Veloz Idalia | Castruita-De la Rosa Claudia | Cortes-Flores Raul | Martinez-Gaytan Victoria | Rivera-Muñoz Jose | Garcia-Mayorga Elda | Meza-Lamas Esteban | Rojas-Martinez Augusto | Ortiz-Lopez Rocio | Martinez-Fierro Margarita

Journal: BMC Pregnancy and Childbirth
ISSN 1471-2393

Volume: 11;
Issue: 1;
Start page: 35;
Date: 2011;
Original page

Abstract Background Preeclampsia (PE) is the first worldwide cause of death in pregnant women, intra-uterine growth retardation, and fetal prematurity. Some vascular endothelial grown factor gene (VEGF) polymorphisms have been associated to PE and other pregnancy disturbances. We evaluated the associations between VEGF genotypes/haplotypes and PE in Mexican women. Methods 164 pregnant women were enrolled in a case-control study (78 cases and 86 normotensive pregnant controls). The rs699947 (-2578C/A), rs1570360 (-1154G/A), rs2010963 (+405G/C), and rs25648 (-7C/T), VEGF variants were discriminated using Polymerase Chain Reaction - Restriction Fragment Length Polymorphism (PCR-RFLP) methods or Taqman single nucleotide polymorphism (SNP) assays. Results The proportions of the minor allele for rs699947, rs1570360, rs2010963, and rs25648 VEGF SNPs were 0.33, 0.2, 0.39, and 0.17 in controls, and 0.39, 0.23, 0.41, and 0.15 in cases, respectively (P values > 0.05). The most frequent haplotypes of rs699947, rs1570360, rs2010963, and rs25648 VEGF SNPs, were C-G-C-C and C-G-G-C with frequencies of 0.39, 0.21 in cases and 0.37, 0.25 in controls, respectively (P values > 0.05) Conclusion There was no evidence of an association between VEGF alleles, genotypes, or haplotypes frequencies and PE in our study.
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