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No major association between TGFBR1*6A and prostate cancer

Author(s): Kaklamani Virginia | Baddi Lisa | Rosman Diana | Liu Junjian | Ellis Nathan | Oddoux Carole | Ostrer Harry | Chen Yu | Ahsan Habibul | Offit Kenneth | Pasche Boris

Journal: BMC Genetics
ISSN 1471-2156

Volume: 5;
Issue: 1;
Start page: 28;
Date: 2004;
Original page

Abstract Prostate cancer is the most commonly diagnosed cancer in men and one of the leading causes of cancer deaths. There is strong genetic evidence indicating that a large proportion of prostate cancers are caused by heritable factors but the search for prostate cancer susceptibility genes has thus far remained elusive. TGFBR1*6A, a common hypomorphic variant of the type I Transforming Growth Factor Beta receptor, is emerging as a tumor susceptibility allele that predisposes to the development of breast, colon and ovarian cancer. The association with prostate cancer has not yet been explored. A total of 907 cases and controls from New York City were genotyped to test the hypothesis that TGFBR1*6A may contribute to the development of prostate cancer. TGFBR1*6A allelic frequency among cases (0.086) was slightly higher than among controls (0.080) but the differences in TGFBR1*6A genotype distribution between cases and controls did not reach statistical significance (p = 0.67). Our data suggest that TGFBR1*6A does not contribute to the development of prostate cancer.

Tango Jona
Tangokurs Rapperswil-Jona

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