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The non-alcoholic fatty liver disease’s progression is associated to obesity and hepatic oxidative stress

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Author(s): Rodrigo Andrés Carrasco Loza | Rodrigo Luis Castillo Peñaloza | Patricio Andrés Huerta Bustamante | Lilian Thieleman

Journal: MedUNAB
ISSN 0123-7047

Volume: 6;
Issue: 16;
Start page: 15;
Date: 2003;

Keywords: Liver | oxidative stress | proteins oxidation | antioxidant capacity of serum

ABSTRACT
The non-alcoholic fatty liver disease (NAFLD) is a clinical and histological entity whose etiology seems to be multifactorial, and its contributory mechanisms are poorly understood. Evidence suggests that oxidative stress is developed in the liver of NAFLD patients. The aim of this study was to assess hepatic and plasma parameters related to oxidative stress as a function of histologicalfindings of NAFLD. Fifty patients with NAFLD were studied (male/female, 10/40; average age, 41 years). We measured in liver samples, the following: Protein carbonyl content (as index of protein oxidation), superoxide dismutase(SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities and the ferric reducing ability of plasma (FRAP). We found livers with 32% steatosis, 34% steatohepatitis,and 34% steatohepatitis and fibrosis. In patients with steatosis there was a 147% more protein oxidation than in those with steatohepatitis and 163% higher than in those with steatohepatitis and fibrosis (p
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