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Non-Hodgkin lymphoma and GIST: molecular pathways and clinical expressions

Author(s): Karanikas M | Machairiotis N | Zarogoulidis P | Stylianaki A | Courcoutsakis N | Mitrakas A | Touzopoulos P | Lyratzopoulos N | Kouklakis G | Spanoudakis M | Polychronidis A

Journal: OncoTargets and Therapy
ISSN 1178-6930

Volume: 2012;
Issue: default;
Start page: 433;
Date: 2012;
Original page

Michael Karanikas,1 Nikolaos Machairiotis,2 Paul Zarogoulidis,3,4 Aikaterini Stylianaki,3 Nikolaos Corcoutsakis,5 Alexandros Mitrakas,1 Panagiotis Touzopoulos,1 Nikolaos Lyratzopoulos,1 George Kouklakis,6 Manolis Spanoudakis,7 Alexandros Polychronidis111st University Surgery Department, 2Surgery Department, University General Hospital of Alexandroupolis, Alexandroupolis, Greece; 3Pulmonary Department-Oncology Unit, G. Papanikolaou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece; 4Pulmonary Department-Interventional Unit, Ruhrland Clinic, University of Duisburg-Essen, Essen, Germany; 5Radiology Department, 6Endoscopy Unit, 7Hematology Department, University General Hospital of Alexandroupolis, Alexandroupolis, GreeceAbstract: We report the case of a 64-year-old woman with a gastrointestinal stromal tumor and a diffuse large cell lymphoma. For this case, we conducted a literature review in an attempt to correlate these two neoplasms on a molecular basis. Diffuse large cell lymphoma is a subtype of non-Hodgkin lymphomas. The etiologic factor of these lymphomas is considered to be the mutations or allelic losses of the TP53 tumor suppressor gene and the overexpression of the bcl-2 oncogene. Gastrointestinal stromal tumors are mesenchymal tumors, which are typically defined by the expression of c-KIT (CD117) and CD34 genes in the tumor cells. Although there are references to dispersants in the literature about patients with both non-Hodgkin lymphoma and gastrointestinal stromal tumors, there is no common molecular pathway between these two diseases. In conclusion, there is no indication that these two neoplasms are relevant on a molecular basis.Keywords: hematological malignacies, mesenchymal cells, gastrointestinal cancer
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