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Nosocomial Bacterial Infections and Their Antimicrobial Resistance Patterns in University Hospitals of Hamedan, Iran

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Author(s): Hashemi SH, Mamani M, Jamal-Omidi S, Niayesh A

Journal: Journal of Research in Health Sciences
ISSN 1682-2765

Volume: 10;
Issue: 1;
Start page: 54;
Date: 2010;
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Keywords: Nosocomial infection | Intensive care units | Antimicrobial resistance

ABSTRACT
Background: Nosocomial infections constitute a global health problem, leading to a high rate of morbidity and mortality. The aim of this study was to determine the frequency and antimicrobial resistance patterns of nosocomial infections in edu¬cational hospitals of Hamadan, western Iran.Methods: During a 1-year period from April 2006 to March 2007, all patients with cul¬ture-proven nosocomial infections from educational hospitals in Hamedan, west¬ern Iran were included. Nosocomial infections were defined as a culture-proven infection, which occurred more than 48h after admission in the hospital. An¬timicrobial susceptibility testing of isolated bacteria was performed by disc dif¬fusion method. Results: A total of 170 cases of culture-proven nosocomial infections were diag¬nosed. Most cases were in intensive care units (ICUs) (57.4%). The common sites of infection were lower respiratory tract (51.8%) and urinary tract (31.9%). Kleb¬siella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli, were the most prevalent pathogens (32.7%, 22.9%, and 14.8% respectively). Most en¬terobacteriacea isolates were resistant to third generation cephalosporins. The resis¬tant rates to ceftriaxone were 75.5% for K. pneumoniae, and 76% for E. coli. Among P. aeruginosa isolates, 26.5% were resistant to ceftazidim, and 36% to cipro¬floxacin. Among S. aureus isolates, 80% were methicillin-resistant. Conclusion: The patients in the ICUs are at a higher risk of nosocomial infec-tions. The high prevalence of antimicrobial resistance in the hospitals highlights the need of further infection control activities and surveillance programs.
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