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Nostoc piscinale Gt-319, a New Cyanobacterial Strain with Cytotoxic Activity

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Author(s): Eshrat Gharaei-Fathabad | Mojtaba Tabatabaei Yazdi | Seyed-Naser Ostad | Shadman Shokravi | Zargham Sepehrizadeh | Mohammad Ali Faramarzi | Mohsen Amini

Journal: Biotechnology
ISSN 1682-296X

Volume: 6;
Issue: 4;
Start page: 505;
Date: 2007;
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Keywords: Nostoc piscinale | cyanobacteria | cytotoxicity | 16S rRNA | cell lines

ABSTRACT
A total of 100 supernatants and methanol extract samples obtained from three weeks’ incubation of 50 different isolate strains of cyanobacteria with paddy-fields origin were investigated for their cytotoxicity properties. Fifteen supernatants and 10 methanol extract samples exhibited cytotoxic activity against Balb-C cells while one methanol extract sample possessed a cytotoxic effect against five different cell lines including HeLa, Vero, Caco-2, HepG-2 and CHO more than vincristine, 5-fluorouracil and methotrexate when used at their IC50 concentrations. The later potent extract was achieved from the cyanobacterium strain GT-319. It was characterized as Nostoc piscinale Kützing ex Bornet and Flahault 1888 according to the morphological studies. Identification of the species was performed following molecular taxonomy by 16S rRNA sequencing. This is the first report on the cytotoxic activity of N. piscinale GT-319.
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