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Novel lipid-based micro formulation and optimization of etoricoxib loaded solid lipid microparticles by using response surface methodology

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Author(s): Subhra Prakash Bhattacharyya*1, 1Debapriya Sarkar, 1Indrani Bhattacharyya, 1Pintu Dey, 2Bhaskar Mazumder

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 9;
Start page: 3136;
Date: 2011;
Original page

Keywords: Etoricoxib | Optimization | Surface Response Model | Lipid Micro Particles

ABSTRACT
Lipid-based delivery systems are becoming increasingly popular as carriers of drugs due to their ability to overcome barriers to oral absorption during the last 10–15 years. the formulation of drugs as microcrystal has rapidly evolved into a mature drug delivery strategy. The major characteristic of these systems is the rapiddissolution velocity, enabling bioavailability enhancement after oral administration. The aim of this research work is to formulate Etoricoxib loaded solid lipidmicroparticles and optimized by response surface methodology. Etoricoxib, a poorly water-soluble non-steroidal anti-inflammatory drug (NSAID). Etoricoxibsolid lipid microparticles (SLM) dispersions were prepared by hot homogenization technique by using different ratio of stearic acid and tripalmitin as lipid anddifferent amount of Pluronic-F-68 as emulsifier. A central composite design for 2 factors at 3 levels each was employed to systematically optimize the particle size,drug entrapment efficiency and drug release in 1 hour. Response surface plots and contour plots were drawn, and optimum formulations were selected by the valuewhich is nearer to the predicted value. The SLM were characterized, in terms of particle size distribution, analyzed by Mastersizer (Malvern Instruments Ltd.),compatibility analyzed by Differential scanning calorimetry (DSC) and FTIR and surface morphology was studied by SEM. The effect of the 2 factors on thevarious response variables, the study helped in finding the optimum formulation with excellent dissolution profile and stability.
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