Academic Journals Database
Disseminating quality controlled scientific knowledge

Novel snake papillomavirus does not cluster with other non-mammalian papillomaviruses

ADD TO MY LIST
 
Author(s): Lange Christian | Favrot Claude | Ackermann Mathias | Gull Jessica | Vetsch Elisabeth | Tobler Kurt

Journal: Virology Journal
ISSN 1743-422X

Volume: 8;
Issue: 1;
Start page: 436;
Date: 2011;
Original page

ABSTRACT
Abstract Papillomaviruses (PVs) are associated with the development of neoplasias and have been found in several different species, most of them in humans and other mammals. We identified, cloned and sequenced PV DNA from pigmented papilloma-like lesions of a diamond python (Morelia spilota spilota). This represents the first complete PV genome discovered in a Squamata host (MsPV1). It consists of 7048 nt and contains the characteristic open reading (ORF) frames E6, E7, E1, E2, L1 and L2. The L1 ORF sequence showed the highest percentage of sequence identities to human PV5 (57.9%) and Caribbean manatee (Trichechus manatus) PV1 (55.4%), thus, establishing a new clade. According to phylogenetic analysis, the MsPV1 genome clusters with PVs of mammalian rather than sauropsid hosts.

Tango Rapperswil
Tango Rapperswil

     Save time & money - Smart Internet Solutions