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Nutritional control of HIV-AIDS-A case for Selenium

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Author(s): Parisa Kalantari | Hema Vunta | Umamaheswari D. Palempalli | C. C.  Reddy | Andrew J. Henderson | K. Sandeep Prabhu

Journal: American Journal of Infectious Diseases
ISSN 1553-6203

Volume: 3;
Issue: 4;
Start page: 195;
Date: 2007;
Original page

Keywords: Tat | NF-kB | thioredoxin reductase | transcription

ABSTRACT
Selenium (Se) is a micronutrient that is incorporated into proteins. Some of the selenoenzymes such as GPXs and thioredoxin reductases exhibit glutathione peroxidase-dependent activities towards organic and inorganic peroxides. Thus, selenoenzymes play a pivotal role in mitigating oxidative stress caused by accumulation of peroxides. In this respect, selenoproteins may interfere with the transcription-driven by oxidative stress-dependent signaling mechanisms to influence the expression of redox sensitive genes, including inflammatory cytokines and HIV provirus. Several epidemiological studies support our view that Se supplementation affects transcription of HIV; however, the underlying mechanism is not elucidated. In this mini review, we consider the relationship between Se and HIV and propose possible mechanisms by which Se controls HIV transcription.
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Tango Jona
Tangokurs Rapperswil-Jona