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Observation of Peptide-Ion Generation by Laser-Induced Surface Heating from Tungsten Silicide Surfaces

Author(s): Shin Hye Kim | Sun Hwa Park | Jae Yong Song | Sang Yun Han

Journal: Mass Spectrometry Letters
ISSN 2233-4203

Volume: 3;
Issue: 1;
Start page: 18;
Date: 2012;

Keywords: Laser desorption/ionization (LDI) | Tungsten silicide (WSi2) | Laser-induced surface heating

We report observation of laser desorption/ionization (LDI) of peptides from flat surfaces of tungsten silicide (WSi2).In contrast to MALDI (matrix-assisted laser desorption/ionization) and SALDI (surface-assisted laser desorption/ionization)mass spectrometry, this study did not utilize any matrices and surface nanostructures. In this work, LDI on WSi2 surfaces is demonstratedto cover a mass range up to 1,600 Da (somatostatin; monoisotopic mass = 1637.9 Da). In addition, it exhibited a highsensitivity, which could detect peptides, which could detect peptides of low femtomole levels (20 fmol for angiotensin II). Theobserved LDI process was discussed to be largely thermal, more specifically, due to laser-induced surface heating that is mostlikely promoted by the low thermal diffusivity (κ) of WSi2 substrate.
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