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Ohtahara syndrome and IVF: A case report

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Author(s): Ashrafi NR

Journal: Acta Medica Iranica
ISSN 0044-6025

Volume: 38;
Issue: 1;
Start page: 18;
Date: 2000;
Original page

Keywords: Ohtahara syndrome | Early infantile epileptic encephalopathy | In vitro fertilization | Suppression burst | Cerebral dysgenesis | Hemimegalencephaly | Intractable seizures

ABSTRACT
Ohtahara syndrome or ealy infantile epileptic encephalopathy is a rare cause of epileptic seizures during infancy and represents the earliest type of age related symptomatic generalized epilepsies. The main etiologic factor associated with ohtahara syndrome is cerebran dysgenesis. This case was the product of in vitro fertilization (IVF) after 18 years of infertility . Neuroimaging findings consisted of diffuse white matter abnormalities, cortical atrophy and hemimegalencephaly. There is a previous report of this syndrome from Canada that was conceived throught IVF. A relation between IVF and the occurrence of Ohtahara synforme needs further observations.

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