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Olfactory Ensheathing Glia: Drivers of Axonal Regeneration in the Central Nervous System?

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Author(s): Moreno-Flores M. Teresa | Díaz-Nido Javier | Wandosell Francisco | Avila Jesús

Journal: Journal of Biomedicine and Biotechnology
ISSN 1110-7243

Volume: 2;
Issue: 1;
Start page: 37;
Date: 2002;
Original page

ABSTRACT
Olfactory ensheathing glia (OEG) accompany olfactory growing axons in their entry to the adult mammalian central nervous system (CNS). Due to this special characteristic, considerable attention has been focused on the possibility of using OEG for CNS regeneration. OEG present a large heterogeneity in culture with respect to their cellular morphology and expressed molecules. The specific characteristics of OEG responsible for their regenerative properties have to be defined. These properties probably result from the combination of several factors: molecular composition of the membrane (expressing adhesion molecules as PSA-NCAM, L1 and/or others) combined with their ability to reduce glial scarring and to accompany new growing axons into the host CNS. Their capacity to produce some neurotrophic factors might also account for their ability to produce CNS regeneration.
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