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Oral Administration of Lasalocid Causes Peripheral Neuropathy in Sprague Dawley Rats:Effect of Water Salinity on Lasalocid-induced Peripheral Neuropathy

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Author(s): Asim Kart | Stanley Leon Vanhooser | Subbiah Sangiah

Journal: Journal of Animal and Veterinary Advances
ISSN 1680-5593

Volume: 4;
Issue: 8;
Start page: 719;
Date: 2005;
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Keywords: Lasalocid | ataxia | neurotoxicity | heat stress | salinity

ABSTRACT
Lasalocid toxicity was associated with several neurotoxicity cases in animal species. Incidence of lasalocid neurotoxiciy shows a higher rate in chickens during heat stress with increased water salinity. In the present study, It studied the effect of lasalocid with or without 0.9 % NaCl in male Sprague Dawley. The rats were given 0, 10, 20, 40 mgkgG of lasalocid two times a day for 3 days with or without 0.9 % saline in the 1 drinking water. Rats showed ataxia in the 20 and 40 mgkgG dose groups with higher death rate in group 1 receiving 40 mgkgG of lasalocid. Dietary salt did not affect ataxia induced by lasalocid. While the optimum dose 1 to produce ataxia (without high mortality) appears to be 20 mgkgG of lasalocid, increasing salinity of water has 1 no effect on the neurotoxicity of lasalocid.
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