Academic Journals Database
Disseminating quality controlled scientific knowledge

Oral Iron Chelators: A New Avenue for the Management of Thalassemia Major

ADD TO MY LIST
 
Author(s): Ritesh N. Sharma and S. S. Pancholi

Journal: Journal of Current Pharmaceutical Research
ISSN 0976-3171

Volume: 1;
Issue: 1;
Start page: 1;
Date: 2010;
VIEW PDF   PDF DOWNLOAD PDF   Download PDF Original page

Keywords: Thalassemia | Transfusion | Oral iron chelation

ABSTRACT
Removal of iron excess is the core of the treatment of iron overload caused by multiple transfusions for thalassemia syndrome. Chronically transfused patients develop overload that leads to organ damage and ultimately to death. This review deals with the advances in iron chelating therapy. Regular subcutaneous administration of deferoxamine has dramatically altered the prognosis of thalassemia major and is considered the standard iron chelation therapy at present. Deferiprone is a first orally active iron chelator to reduce body iron to concentrations compatible with the avoidance of complications from iron over loading patients with thalassemia. Another chemical agent has recently been developed as oral active iron chelator; ICL-670 (Deferasirox) for the treatment of iron overload. It is tridentate oral iron chelator having low molecular weight with high selectivity and specificity for iron. The oral iron chelation therapy is the demand of present scenario to fight against the thalassemia major.
Save time & money - Smart Internet Solutions      Why do you need a reservation system?