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Outcome of Subsequent Pregnancies in Familial Molar Pregnancy

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Author(s): Masoumeh Fallahian | Forough Foroughi | Mohammad Vasei | Shahrzad Tavana | Maryam Ghanbary | Maryam Monajemzadeh | Anahita Tavana

Journal: International Journal of Fertility & Sterility
ISSN 2008-076X

Volume: 7;
Issue: 1;
Start page: 63;
Date: 2013;
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Keywords: Hydatidiform Mole | Familial | Outcome of Pregnancy | Normal Pregnancy

ABSTRACT
Familial recurrent molar pregnancy is an exceedingly rare condition, in which completehydatidiform moles are mostly diploid but biparental in origin and the outcome of subsequentpregnancies is likely to be a hydatidiform mole or other type of reproductiveloss. We previously reported a case of familial molar pregnancy (family K) comprisingfive affected members (four sisters and one of their cousins) each with at least one hydatidiformmole (HM). In addition to the molar pregnancies, these patients have a total ofthree miscarriages and 8 normal pregnancies leading to healthy children; but the youngestmember of this family has given birth to a boy with Down syndrome.Our second family (case S) includes two sisters with diploid biparental complete moles.They have a total of six molar pregnancies with no living child. Recently the younger sisterhad a partial molar pregnancy with apparently normal XX fetus accompanying diffusemolar changes of the placenta that led to preeclampsia and preterm delivery.Overall, these families have had 26 pregnancies including 12 molar pregnancies (completeor partial) and three abortions.We concluded that these families are predisposed to various genetic mutations, chromosomalabnormalities and clinical manifestations, which affect their offspring. Furtherstudies of patients are needed to determine any relationship between a history of familialmolar pregnancy and trisomy or other chromosomal abnormalities in offspring and geneticmutations in the products of conception to complete the puzzle and manage familialmolar pregnancy.
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