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Overview of Multidrug-Resistant <i>Pseudomonas aeruginosa</i> and Novel Therapeutic Approaches

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Author(s): Marilyn Porras-Gómez | José Vega-Baudrit | Santiago Núñez-Corrales

Journal: Journal of Biomaterials and Nanobiotechnology
ISSN 2158-7027

Volume: 03;
Issue: 04;
Start page: 519;
Date: 2012;
Original page

Keywords: Bacilli | Gram-Negative | Pseudomonas aeruginosa | Multidrug Resistance | Pathogen | Resistance Mechanisms

ABSTRACT
Gram-negative bacilli Pseudomonas aeruginosa is an important pathogen in hospitalized patients, contributing to their morbidity and mortality due to its multiple resistance mechanisms. Therefore, as therapeutic options become restricted, the search for new agents is a priority. Latterly an accelerated increase in frequency of multidrug-resistant clinical strains has severely limited the availability of therapeutic options. Several in vitro and in vitro studies evaluating the efficacy of different antimicrobials agents and development of vaccines against P. aeruginosa have been reported as novel approaches, such as inhibition of virulence factor expression or inhibition of their metabolic pathways.
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