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An overview on nanocarrier technology- Aquasomes

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Author(s): Shahabade Gururaj S*,Bhosale Ashok V,Mutha Swati S.,Bhosale Nilesh R.,Khade Prashant H.,Bhadane Nishant P.,Shinde Sagar T.

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 2;
Issue: 7;
Start page: 1174;
Date: 2009;
Original page

Keywords: Aquasomes | self assembling carrier system | nanoparticles.

ABSTRACT
Aquasomes are the nanobiopharmaceutical carrier system contains the particle core composed of nanocrystalline calcium phosphate or ceramic diamond, and is covered by a polyhydroxyl oligomeric film. Aquasomes are spherical 60–300 nm particles used for drug and antigen delivery. Properties like protection and preservation of fragile biological molecules, conformational integrity, and surface exposure made it as a successful carrier system for bioactive molecules like peptide, protein, hormones, antigens and genes to specific sites. Three types of core materials are mainly used for producing aquasomes: tin oxide, nanocrystalline carbon ceramics (diamonds) and brushite (calcium phosphate dihydrate). Calcium phosphate is the core of interest, owing to its natural presence in the body. The brushite is unstable and converts to hydroxyapatite upon prolong storage. Hydroxyapatite seems, therefore, a better core for the preparation of aquasomes. It is widely used for the preparation of implants for drug delivery. It has been reported haemoglobin loaded aquasomes using hydroxyapatite core as potential artificial oxygen carrying system. Conformational integrity of aquasomes exploited as a red blood cell substitutes, vaccines for delivery of viral antigen (Epstein-Barr and Immune deficiency virus) to evoke correct antibody and as targeted system for intracellular gene therapy. Enzyme activity and sensitivity towards molecular conformation made aquasome as a novel carrier for enzymes like DNAses and pigment/dyes.This report reviews the principles of self assembly, the challenges of maintaining both the conformational integrity and biochemical activity of immobilized surface pairs, and the convergence of these principles into a single functional composition.
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