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Oxidant/Antioxidant Status in Patients with Behçet Disease

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Author(s): Maather Mahgoub | Hala Raslan | Heba Assal | Tamer Gheita | Iman Fikry | Mehrevan Abd El-Moniem | Mona Anwar

Journal: Macedonian Journal of Medical Sciences
ISSN 1857-5749

Volume: 3;
Issue: 1;
Start page: 37;
Date: 2010;
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Keywords: Behçet’s disease | Nitric oxide | Malondialdehyde | Hydrogen peroxide | Total antioxidant capacity.

ABSTRACT
Background. Increased oxidant stress and decreased antioxidant enzyme activities may result in tissue injury in Behçet’s disease (BD) patients. Aim. The aim of the study was to assess various selected markers of oxidative stress in patients with BD. Material and Methods. Thirty-two patients with BD and twenty-five healthy age- and sex- matched controls were recruited from the Rheumatology Department of Cairo University Hospital. Behçet’s Disease current activity form (BDCAF) was used in order to assess the disease activity. The following parameters were assayed: serum nitric oxide level (NO), serum malondialdehyde (MDA), serum hydrogen peroxide (H2O2), serum total antioxidant capacity (TAC). Reuslts. The present result showed that serum NO and TAC levels were significantly lower in BD patients, than in healthy controls (P

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