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Oxidation Chemistry of 2`-Deoxyinosine at Stationary Solid Electrodes

Author(s): Rajendra Nath Goyal | Anuradha Tyagi

Journal: Asian Journal of Biochemistry
ISSN 1815-9923

Volume: 1;
Issue: 2;
Start page: 106;
Date: 2006;
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Keywords: 2-Deoxyinosine | electrooxidation | purine nucleosides

+, Ia) at both the electrodes. The initial course of the electrode reaction has been deduced to involve a 2e, 2H+ reaction to give 8-hydroxy-2`-deoxyinosine which is further oxidised in a 2e, 2H+ reaction to give 2,8-dihydroxy-2`-deoxyinosine. The 2e, 2H+ oxidation of dihydroxy derivative then gives a diimine species, which undergoes a series of chemical reactions to give different products. In a parallel pathway initial 1e, 1H+ oxidation also occurs to give a free radical, which leads to the formation of dimers. The products of the electrode reaction were separated by HPLC and characterized by m.p., 1HNMR, IR and GC-Mass. A tentative mechanism for the formation of the products has also been suggested.]]>
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