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Oxidative stress and anti-oxidant status in breast cancer patients

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Author(s): Nagulu M1*, Uday KiranV1, ,Nalini K2,Dharak R2 ,Narsimha Reddy Y1,Rama Krishna D1

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 2;
Issue: 1;
Start page: 62;
Date: 2009;
Original page

Keywords: Breast cancer | glutathione | total anti-oxidant status

ABSTRACT
Breast cancer (BC) is a global public health problem as it is the third most common cancer leading to the death of womenworldwide. Reactive oxygen species (ROS) damage DNA, but the role of ROS in breast carcinoma may not be limited tothe mutagenic activity that drives carcinoma initiation and progression. Carcinoma cells in vitro and in vivo are frequentlyunder persistent oxidative stress. Many references revealed that the low levels of antioxidants induce the generation of freeradicals leading to DNA damage and further mutations. In the present study, an attempt has been made to evaluate thelevels of serum Glutathione [GSH] and Total anti-oxidant status [TAS]. Total 65 subjects were selected for study. Out of65 subjects 20 were NHVs (control group) and 45 were untreated BC patients. The female patients within the age groupof 25-65 years were selected. They were clinically and histopathologically diagnosed for BC.20 healthy female subjectsfrom the same economic status, having no history of smoking, alcoholism, any type of carcinoma etc were treated ascontrols. Significantly decreased values of GSH and TAS were observed (p

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