Academic Journals Database
Disseminating quality controlled scientific knowledge

Oxidative stress in rat liver during acute cadmium and ethanol intoxication

Author(s): Radosavljević Tatjana | Mladenović Dušan | Ninković Milica | Vučević Danijela | Boričić Ivan | Ješić-Vukićević Rada | Šljivančanin Tamara | Lopičić Srđan | Todorović Vera

Journal: Journal of the Serbian Chemical Society
ISSN 0352-5139

Volume: 77;
Issue: 2;
Start page: 159;
Date: 2012;
VIEW PDF   PDF DOWNLOAD PDF   Download PDF Original page

Keywords: ethanol | reactive oxygen species | cadmium | liver injury | rat

The aim of our study was to investigate the effects of binge drinking on prooxidant/antioxidant system in rat liver in acute cadmium (Cd) intoxication. In experiment male Wistar rats were used and divided into following groups: 1. control, 2. ethanol-treated group, in five subsequent doses of 2 g/kg administered by orogastric tube, 3. Cd-treated group in a single dose of 2.5 mg/kg intraperitoneally, 4. group that received Cd 12 hours after the last dose of ethanol. Blood and liver samples were collected for determination of oxidative stress parameters, 24 hours after treatment. When administered in combination, ethanol and Cd induced a more pronounced increase in serum and liver malondialdehyde level than either of these substances alone (p
Save time & money - Smart Internet Solutions      Why do you need a reservation system?