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Palmoplantar Psoriasis: Treatment with Calcipotriol and Local UVA Radiation Compared with Local PUVA

Author(s): Nikolai Tsankov | Simin Meymandi | Ivan Grozdev | Hamidreza Shafiei

Journal: Journal of Lasers in Medical Sciences
ISSN 2008-9783

Volume: 2;
Issue: 1;
Start page: 1;
Date: 2011;
Original page

Keywords: Psoriasis | palmo-plantar | Calcipotriol | Psoralen | Clinical Trial

Abstract: Introduction: Palmoplantar psoriasis could hardly be differentiated from chronic tylotic eczema both clinically and histologically. The most commonly used therapeutic options for palmoplantar psoriasis are long-term therapy with topical corticosteroids and local PUVA. Frequently, it is a recalcitrant disease. We investigated the efficacy and tolerability of the combination of topical calcipotriol with local UVA radiation in comparison with local PUVA therapy. Materials and Methods: In a total of 43 patients with palmoplantar psoriasis, 33 were given 15 sessions of local UVA radiation and topical calcipotriol and the remainder received 15 sessions of local PUVA (psoralen + UVA radiation). Results: The statistical analyses of the results showed that the effect and tolerability of both therapeutic modalities are comparable. Conclusion: Combination of topical calcipotriol and local UVA radiation is an optional corticosteroid-free therapeutic modality for palmoplantar psoriasis. It has a comparable effectiveness and tolerability with local PUVA. References1. Petty A, Balkrishnan R, Rapp S, Fleischer A, Feldman S.Patients with palmoplantar psoriasis have more physicaldisability and discomfort than patients with other formsof psoriasis: Implications for clinical practice. J Am AcadDermatol. 2003 August;49(2):271-5.2. Farley E, Masrour Sh, McKey J, Menter A. Palmoplantarpsoriasis: A phenotypical and clinical review withintroduction of a new quality-of-life assessment tool. JAm Acad Dermatol. 2009 Jun;60(6):1024-31.3.Adişen E, Tekin O, Gülekon A, Gürer MA. A retrospectiveanalysis of treatment responses of palmoplantar psoriasisin 114 patients. J Eur Acad Dermatol Venereol. 2009July;23(7):814-9.4. Davis MD, McEvoy MT, el-Azhary RA. Topical psoralenultravioletA therapy for palmoplantar dermatoses:experience with 35 consecutive patients. Mayo ClinProc. 1998 May;73(5):407-11.5. Egawa K. Topical vitamin D3 derivatives in treatinghyperkeratotic palmoplantar eczema: a report of fivepatients. J Dermatol. 2005 May;32(5):381-6.6. Scott LJ, Dunn CJ, Goa KL. Calcipotriol ointment. Areview of its use in the management of psoriasis. Am JClin Dermatol 2001;2(2):95-120.7. Roussaki-Schulze AV, Kouskoukis C, Klimi E, ZafiriouE, Galanos A, Rallis E. Objective biophysical findingsin patients with sensitive skin. Drugs Exp Clin Res.2005;31(5-6):169-74.8. Speight EL, Farr PM. Calcipotriol improves the responseof psoriasis to PUVA.Br J Dermatol. 1994 Jan;130(1):79-82. 
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