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Pancreatic Abnormalities at a Young Age in Spontaneously Diabetic Torii (SDT) Rats

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Author(s): Takeshi Ohta | Masami Shinohara | Takuji Yamamoto | Takahisa Yamada

Journal: Journal of Animal and Veterinary Advances
ISSN 1680-5593

Volume: 11;
Issue: 9;
Start page: 1322;
Date: 2012;
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Keywords: HOMA | IGT | SDT rat | reduction | insulin content | pancreatic

ABSTRACT
The Spontaneously Diabetic Torii (SDT) rat is a non-obese diabetic model showing various metabolic abnormalities in pre-diabetic stage. In this study, researchers investigated the pancreatic function at young ages, 5 and 7 weeks. At 5 weeks, SDT rats showed glucose intolerance and reduction of Homeostasis Model Assessment (HOMA)-β. At 7 weeks, the insulin content in pancreas was also decreased. Insulinogenic index showed no change at 5 and 7 weeks of age. In conclusion, the pancreatic function in SDT rats was decreased from a young age after weaning and the rat is a useful Animal Model to examine the pathophysiological features of Impaired Glucose Tolerance (IGT).
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