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Parameters оf cytokine regulation as additional criterion of immunodiagnosis

Author(s): Ter-Pogosyan Z. R.

Journal: Biopolymers and Cell
ISSN 0233-7657

Volume: 27;
Issue: 5;
Start page: 404;
Date: 2011;
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Keywords: cytokins | immunodiagnostics | tumors | polytrauma | sepsis

Aim. The work goal was to search more informative parameters of cytokine system for laboratory diagnosis in oncological and non-oncological pathology. Methods. The concentrations of some cytokines and chemokines (IL-4, 6, 8 and raIL-1), interferones (IFN-alpha, gamma), (VEGF) have been investigated. Results. Outcoming levels of investigated cytokines have exceeded the norm mostly in patients with malignant tumor of brain. The serum level raIL-1 increased in patients with lung cancer and a decrease of this indicator was detected by the end of treatment. Concentration of IL-8 in blood serum, initially increased, in majority of them, 82 %, remained at the previous level by the end of investigation; the averaged level IL-6 was slightly increased and decreased by the end of investigation approximately reaching the norm limits. Serum level raIL-1 increased in 70 % of patients with polytrauma and decreased by the end of treatment. Indicators IL-6 and IL-8 in the same patients initially increased and slightly decreased by the end of investigation. Concentration of VEGF in patients with high level malignancy (G3) comprised 285.9 ± 27.2 pg/ml with a slight increase by the end of investigation while in low level malignancy a reliable decrease in its content was detected. The serum level VEGF in patients with polytrauma increased by the end of investigation, thus in majority of investigated patients with favorable illness process statistically sufficient decrease was detected. Conclusions. The results obtained will help to select much more informative biomarkers that have diagnostic and prognostic importance
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