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Participation of mast cells in chronic otitis media

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Author(s): Anna Pajor | Marian Danilewicz | Andrzej Jankowski | Tomasz Durko

Journal: Folia Histochemica et Cytobiologica
ISSN 0239-8508

Volume: 49;
Issue: 3;
Start page: 479;
Date: 2011;
Original page

Keywords: chronic otitis media | granulation tissue | mast cells | tryptase

ABSTRACT
In the pathogenesis of chronic otitis media (COM), much attention is paid to the molecular mechanismsof local inflammatory reactions in which mast cells (MCs) may be involved due to their role not only in allergic butalso inflammatory processes. The aim of this study was to assess the density of mast cells in chronic otitis media inrelationship to different clinical courses of COM, bacterial infections and types of disease. The MCs expressionwas measured immunohistochemically in paraffin-embedded granulation tissue specimens taken during surgery,by staining with a monoclonal antibody against tryptase. The density of tryptase-positive mast cells was lower intissue samples from the group with a good clinical course than in those from the group with poor healing andrecurrence (p = 0.006). There were no differences between the groups of patients with granulomatous and cholesteatomatouschronic otitis media (p = 0.66) or between the groups of patients with and without bacterial infection(p = 0.30), although the density of mast cells was lower for those with Pseudomonas aeruginosa/Proteus sp.//Staphyloccocus MRSA infection. In conclusion, the expression of mast cells in chronic otitis media granulationtissue was found to differ depending on the clinical course of the disease, but not on bacterial infection or type ofCOM. This may suggest that mast cells contribute to the maintenance of the inflammatory process, but not toantibacterial defense in chronic otitis media. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 3, pp. 479–485)
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