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Particulate vaccine for bacterial diseases

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Author(s): Hariprasad O. | Gopinath V.P. | Navya A. | Yugandhar V.G. | Sarma P.V.G.K.

Journal: International Journal of Drug Discovery
ISSN 0975-4423

Volume: 2;
Issue: 2;
Start page: 17;
Date: 2010;
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Keywords: Immune response | Sero conversation | Antigenicity | Nanoparticles and Vaccination

ABSTRACT
Particulate vaccines made a remarkable break through in the vaccines and drugdelivery systems. With their fine small structure they can pass through the cellular systemsand can trigger the type I and type II immune systems, which aid in the better immuneresponse. The sero conversation and the longevity of the particulate vaccines are found to bebetter than the regular conventional vaccines. The development of recombinant vaccines andsub unit vaccines having safer side in vaccination could not elicit stronger immune response,because of their partial antigenicity. In such cases when coupled with nanoparticles triggersbetter immune response. Recombinant Tetanus toxoid and Diphtheria toxoid when coupledwith nanoparticles showed significant TH1 and TH2 immune responses. Particulate vaccinescan be used in mucosal, nasal, ocular or transcutaneous modes for vaccination.
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