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Passiflora incarnata Linn. leaf extract as neuroprotective agent in MPTP induced Parkinson’s disease in mice

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Author(s): Ramji Narayanan*, Palayan Muralidharan

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 9;
Start page: 3108;
Date: 2011;
Original page

Keywords: Parkinson’s disease | Passiflora incarnata Linn. | 1-methyl-4-phenyl-1 | 2 | 3 | 6-tetrahydropyridine (MPTP) | Neurodegeneration

ABSTRACT
To examine effect of Passiflora incarnata Linn. on neurochemical and behavioral abnormalities as seen in Parkinson’s disease (PD) using micemodel. Materials and methods: Mice were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) for 4 days to show neurochemical andbehavioral abnormalities similar to patients with PD. PD mice were treated with methanolic leaf extract of Passiflora incarnata Linn. (PIL) 200 mg/kg and 400mg/kg body weight (p.o) for 14 days. Neurochemicals such as Dopamine (DA), Monoamine oxidase B (MAOB) enzyme and Glutamate; Antioxidants like Super oxidedismutase (SOD), Glutathione peroxidase (GPx) and reduced Glutathione were analyzed in the PIL treated and untreated PD mice striatum. Behavioral abnormalitiesin the mice were determined by rotarod test, Pole test, Catalepsy test, Beam walk test, Gait analysis and Adhesive removal test. Results: Mice treated withMPTP showed reduced levels of DA, increased MAO B enzyme and Glutamate level compared to the control. Oral treatment of PIL (200mg/kg and 400mg/kg bodyweight) for 14 days significantly increased DA, and decreased the MOAB enzyme and Glutamate levels in the corpus striatum of the PD mice. The antioxidantssuch as SOD, Gpx and reduced glutathione levels were also impaired in PD mice striatum and were restored upon PIL treatment. The 14 days PIL treated miceshowed improved behavioral function. Conclusion: These data shows that PI is a potential agent in treating neurochemical and behavioral abnormalities seenin the PD mouse
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