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Pathogenesis, etiology and treatment of bronchiectasis

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Author(s): AL-Shirawi Nehad | AL-Jahdali Hamdan | Al Shimemeri Abdullah

Journal: Annals of Thoracic Medicine
ISSN 1817-1737

Volume: 1;
Issue: 1;
Start page: 41;
Date: 2006;
Original page

Keywords: Bronchiectasis | chronic lung disease

ABSTRACT
Bronchiectasis is a chronic lung disease, defined pathologically as irreversible dilatation of the bronchi. The clinical course of the disease is chronic and progressive and in most cases, causes lung damage over many years. There is usually an initial event, which causes impairment of mucociliary clearance of the bronchial tree. The respiratory tract becomes colonized by bacteria that inhibit the ciliary function and promote further lung damage. The hallmark of bronchiectasis, is a chronic cough with mucopurulent or purulent sputum, lasting for months to years and may progress to chronic respiratory failure. Diagnosis of bronchiectasis is suspected on the basis of clinical manifestations. In order to confirm the diagnosis and underlying causes, appropriate investigations must be performed. In this comprehensive review, we discuss the etiology, pathogenesis, clinical presentation, appropriate investigations and management of bronchiectasis.
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