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Pathology of Ewing′s sarcoma/PNET: Current opinion and emerging concepts

Author(s): Desai Saral | Jambhekar Nirmala

Journal: Indian Journal of Orthopaedics
ISSN 0019-5413

Volume: 44;
Issue: 4;
Start page: 363;
Date: 2010;
Original page

Keywords: Ewing′s sarcoma | EWS-FLI1 translocation | pathology | PNET

Ewing′s sarcoma/PNET are small round cell tumors showing a varying degree of neuroectodermal differentiation. They are one of the commonest tumors of childhood and occur in bone and within soft tissues. Traditionally, light microscopy with the aid of immunohistochemical stains was suitable for diagnosis. But now translocation analyses are being used not only for the diagnosis and classification of small round cell tumors, but to ascertain their prognostic significance, detect micrometastasis, and monitor minimal residual disease, with potential for targeted therapy. This article analyzes the pathology, biology, and molecular aspects of Ewing′s sarcoma/PNET and discusses their clinical and therapeutic implications.
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