Author(s): Pitchai Balakumar | Bharat Pateliya | Gurfateh Singh | Manjeet Singh
Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657
Volume: 7;
Issue: 1;
Start page: 115;
Date: 2008;
Original page
Keywords: Ischemia/reperfusion injury | Preconditioning | Postconditioning
ABSTRACT
Organ damage after reperfusion of previously viable ischemic tissues is defined as ischemia/reperfusion injury. The pathophysiology of ischemia/reperfusion injury involves cellular effect of ischemia, reactive oxygen species and inflammatory cascade. Protection against ischemia/reperfusion injury may be achieved by preconditioning or postconditioning. In this review, we discuss basic mechanisms involved in the pathophysiology of ischemia/reperfusion injury. Moreover, the pharmacology of preconditioning and postconditioning is delineated.
Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657
Volume: 7;
Issue: 1;
Start page: 115;
Date: 2008;
Original page
Keywords: Ischemia/reperfusion injury | Preconditioning | Postconditioning
ABSTRACT
Organ damage after reperfusion of previously viable ischemic tissues is defined as ischemia/reperfusion injury. The pathophysiology of ischemia/reperfusion injury involves cellular effect of ischemia, reactive oxygen species and inflammatory cascade. Protection against ischemia/reperfusion injury may be achieved by preconditioning or postconditioning. In this review, we discuss basic mechanisms involved in the pathophysiology of ischemia/reperfusion injury. Moreover, the pharmacology of preconditioning and postconditioning is delineated.
