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Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome

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Author(s): Smith Craig | Emsley Hedley | Gavin Carole | Georgiou Rachel | Vail Andy | Barberan Elisa | del Zoppo Gregory | Hallenbeck John | Rothwell Nancy | Hopkins Stephen | Tyrrell Pippa

Journal: BMC Neurology
ISSN 1471-2377

Volume: 4;
Issue: 1;
Start page: 2;
Date: 2004;
Original page

Keywords: stroke acute | interleukin-6 | C-reactive protein | inflammation | outcome measures

ABSTRACT
Abstract Background Cerebral ischaemia initiates an inflammatory response in the brain and periphery. We assessed the relationship between peak values of plasma interleukin-6 (IL-6) in the first week after ischaemic stroke, with measures of stroke severity and outcome. Methods Thirty-seven patients with ischaemic stroke were prospectively recruited. Plasma IL-6, and other markers of peripheral inflammation, were measured at pre-determined timepoints in the first week after stroke onset. Primary analyses were the association between peak plasma IL-6 concentration with both modified Rankin score (mRS) at 3 months and computed tomography (CT) brain infarct volume. Results Peak plasma IL-6 concentration correlated significantly (p < 0.001) with CT brain infarct volume (r = 0.75) and mRS at 3 months (r = 0.72). It correlated similarly with clinical outcome at 12 months or stroke severity. Strong associations were also noted between either peak plasma C-reactive protein (CRP) concentration or white blood cell (WBC) count, and all outcome measures. Conclusions These data provide evidence that the magnitude of the peripheral inflammatory response is related to the severity of acute ischaemic stroke, and clinical outcome.

Tango Jona
Tangokurs Rapperswil-Jona

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