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Pectin-Based Biodegradable Hydrogels with Potential Biomedical Applications as Drug Delivery Systems

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Author(s): Mohammad Sadeghi

Journal: Journal of Biomaterials and Nanobiotechnology
ISSN 2158-7027

Volume: 02;
Issue: 01;
Start page: 36;
Date: 2011;
Original page

Keywords: Pectin | Polyacrylonitrile | Hydrogel | Ibuprofen | Drug Delivery

ABSTRACT
In this work, synthesis and swelling behavior of a superabsorbent hydrogel based on Pectin (Pc) and polyacrylonitrile (PAN) were investigated. A mechanism for hydrogel formation was proposed and the structure of the product was es-tablished using FTIR spectroscopy. The Pc-poly (sodium acrylate-co-acrylamide) hydrogel exhibited a pH-responsive swelling-deswelling behavior at pH’s 2 and 8. This on-off switching behavior provides the hydrogel with the potential to control delivery of bioactive agents. Release profiles of ibuprofen (IBU), a poor water-soluble drug, from the hydro-gels were studied under both simulated gastric and intestinal pH conditions.
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