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Pelletization as a key tool for oral drug delivery: A review

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Author(s): Afifa Bathool*, Gowda D. Vishakante, Mohammed S. Khan, Vikas K Gupta

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 10;
Start page: 3282;
Date: 2011;
Original page

Keywords: Multiparticulate systems | pellets | Extrusion-spheronization | evaluation parameters.

ABSTRACT
Multiparticulate systems prove to be promising system for oral drug delivery. Pelletization is a process in which fine powders or granules are converted into freeflowing semi-spherical units referred as pellets. Pellets are the multiple unit dosage forms which can be formulated in the form of suspensions, capsules ordisintegrating tablets. This review outlines manufacturing and evaluation of spherical pellets. The manufacturing techniques include extrusion/spheronization, hotmeltextrusion, layering, globulation, compression, balling, freeze pelletization and cryopelletization. Evaluation of quality of the pellets is discussed withreference to the shape, size distribution, surface morphology, specific surface area, density, friability, tensile strength.
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