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Author(s): V.S. Tegeli*, Y.S. Thorat, U.S. Shivsharan, G.B. Gajeli, S.T. Kumbhar, G.K. Chougule

Journal: International Journal of Drug Formulation and Research
ISSN 2229-5054

Volume: 2;
Issue: 1;
Start page: 52;
Date: 2011;
Original page

Keywords: Carbopol | o/w emulsion | Pemulen | Polyacrylic acid | Polymeric Emulsifier.

Many emulsifiers are currently employed in a wide area of pharmaceutical as well as cosmetologic applications tostabilize the oil-water system. These emulsifiers work on the principle of micelle formation and reduction ofinterfacial tension between two immiscible components. Thus the applicability of many surface active agents asprimary emulsifier is dependent on its HLB range. In contrast to these agents, Pemulen polymeric emulsifier ishaving wider coverage of the stabilization ability due to its unique emulsification mechanism. Pemulen is apolymeric emulsifier composed of a block copolymer consisting of a poly acrylic acid similar to the Carbopol resinspresently used to make aqueous and solvent gels in art conservation. These are novel oil-in-water (o/w) emulsifierswhich provide numerous benefits to emulsions prepared with them. Thus the oil droplets are protected by the veryhigh yield polymeric gel environment formed around the oil droplet by Pemulen and held in place. As a resultPemulen provides a highly stable emulsion. Due to efficient stabilization, it can be used in number of preparationswhich are discussed in this review

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