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Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes

Author(s): Van de Velde Sébastien | Carryn Stéphane | Van Bambeke Françoise | Hill Colin | Tulkens Paul M | Sleator Roy D

Journal: Gut Pathogens
ISSN 1757-4749

Volume: 1;
Issue: 1;
Start page: 23;
Date: 2009;
Original page

Abstract While seven penicillin-binding proteins (PBPs) or PBP-like proteins have been identified either by radiolabelled penicillin binding studies or genomic analysis, only PBP3 has been considered of interest for Beta-lactams activity against Listeria monocytogenes. Herein we reveal that both PBP4 and Lmo0441 (a PBP-like protein) play a direct role in cephalosporin activity in L. monocytogenes while PBP4 additionally has a protective affect against both penicillin and carbapenem.
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